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¹ Department of Plant and Animal Production, Avanos Vocational School, Nevsehir Haci Bektas Veli University, Nevsehir, Turkey
² Department of Pharmaceutical Microbiology, Faculty of Pharmacy, Erciyes University, Kayseri, Turkey
³ Department of Pharmaceutical Botany, Faculty of Pharmacy, Erciyes University, Kayseri, Turkey
⁴ Department of Chemistry, Faculty of Science, Erciyes University, Kayseri, Turkey
⁵ Department of Analytical Chemistry, Faculty of Pharmacy, Erciyes University, Kayseri, Turkey DOI : 10.16882/derim.2019.549151 Viewed : 2298 - Downloaded : 1049 Herein we report a green method for the synthesis of organic-inorganic hybrid nanoflowers using a Trigonella foenum-graecum L. (TF) (Fenugreek seeds) extracts as an organic part and copper ions acting as an inorganic part. The organic-inorganic hybrid nanoflowers using TF seed extract (TF-Cu²⁺ hNFs) were characterized by SEM, XRD, EDX and FTIR. The morphology of the TF-Cu²⁺ hNFs was quite spherical and monodisperse with ∼18μm size. The TF-Cu²⁺ hNF exhibited the effective anti-bacterial activity against Enterococcus faecium, Enterococcus faecalis, Staphylococcus aureus, Bacillus cereus, Salmonella typhi and Escherichia coli at 1- 10 μg ml^-1 concentrations except against Pseudomonas aeruginosa and Haemophilus influenza. However, both TF-Cu²⁺ hNFs and free TF extracts showed any antifungal activities against Candida albicans or Candida glabrata. The study revealed that TF-Cu²⁺ hNFs could be used as a therapeutic agent for microbial infections and has the potential to overcome drug resistance. Keywords : Biomaterials; Organic-inorganic hybrid nanoflowers; Copper; Anti-microbial activity